Suboxone (buprenorphine and naloxone) can cause drug dependence. This means that withdrawal symptoms may occur if you stop using the medicine too quickly.

Withdrawal symptoms may also occur at the start of treatment due to dependence on another drug. Suboxone (buprenorphine and naloxone) is not for occasional “as needed” use. Do not stop taking buprenorphine and naloxone without first talking to your doctor. Your doctor may want to gradually reduce the dose to avoid or minimize withdrawal symptoms.

Seek emergency medical attention or contact your doctor immediately if you experience any of the following serious side effects:

* an allergic reaction- difficulty breathing; closing of the throat, swelling of the lips, tongue, or face; or hives.

* slow breathing

* dizziness or confusion

* liver problems such as yellowing of the skin or eyes, dark colored urine, light colored stools (bowel movements), decreased appetite for several days or longer, nausea, or lower stomach pain.

Other less serious side effects may be more likely to occur. Continue to take Suboxone and talk to your doctor if you experience:

* headache

* pain

* problems sleeping

* nausea

* sweating

* stomach pain

* constipation

Side effects other than those listed here may also occur. Talk to your doctor or treatment provider about any side effect that is bothersome or seems unusual.